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Welcome to another exciting week from the Healthcare and Life Sciences ecosystem! We've got a packed newsletter full of insights, events, and inspiring stories from the heart of innovation.
Table of Contents
🖼️ Brain-Computer Lunch Priorities
News:
🧬 Biotech
🧠 Definium Therapeutics Scores 3rd Straight Phase 3 Win for LSD Formula: Definium’s DT120 significantly reduced symptoms in generalized anxiety disorder, clearing a path for a pivotal FDA filing next year.
🧬 Scholar Rock Reports Positive Phase 3 SAPPHIRE Data for Muscle Loss: Scholar Rock demonstrated that its investigational antibody apitegromab doubled motor function scores in SMA patients without causing direct neurological toxicity.
💔 Novo Nordisk Terminates Two Phase 3 Ziltivekimab Cardiovascular Studies: Novo halted the HERMES and ATHENA trials after a data monitoring committee concluded the anti-IL-6 antibody was unlikely to hit efficacy goals.
👶 Novo Nordisk Hits Primary Endpoint in STEP Young Pediatric Semaglutide Trial: Over 40% of pediatric participants with severe obesity achieved non-obese status after 68 weeks of semaglutide alongside lifestyle intervention.
🧫 Novartis Misses Primary Outcome in Phase 3 Myotonic Dystrophy Study: Novartis disclosed that its muscle-targeting antibody-oligonucleotide conjugate, del-desiran, failed to significantly improve hand opening times in DM1.
💻 Digital Health
🧠 ABILITY Neurotech Completes First-in-Human Brain-Computer Interface: ABILITY successfully implanted its novel BCI neural data platform designed to restore communication and agency for severe neurological impairment.
💻 Nabla Launches Fully On-Device Mac Dictation for Ambient Clinical AI: Nabla debuted a native macOS clinical dictation tool that processes speech entirely on-device while integrating directly into Epic EHR systems.
🩺 Andor Health Integrates ThinkAndor Remote Patient Monitoring into Epic Toolbox: ThinkAndor received official Epic Toolbox designation to expand AI-native remote physiologic monitoring for chronic population health.
🎙️ PointClickCare Unveils Vox Advantage Native Voice AI for Senior Care: PointClickCare launched a voice-enabled documentation platform embedded directly into senior care electronic health records.
🇪🇺 ECDC and EU Joint Research Centre Deploy RAG AI for Outbreak Detection: European health agencies published validation data confirming retrieval-augmented generation models significantly accelerate infectious disease tracking.
⚖️ Regulatory Affairs
☢️ FDA Approves Curium’s Bexlutry Lutetium Lu 177 Dotatate for GEP-NETs: Curium secured FDA clearance for its targeted radiopharmaceutical to treat somatostatin receptor-positive gastroenteropancreatic neuroendocrine tumors.
🇪🇺 EMA CHMP Recommends Approval for Senaparib in Advanced Ovarian Cancer: European regulators issued a positive opinion for Hangzhou Innovera's PARP inhibitor as a maintenance therapy for high-grade ovarian cancer.
🇪🇺 EMA Recommends Authorization for Glepaglutide in Short Bowel Syndrome: The CHMP granted a positive opinion for Zealand Pharma’s long-acting GLP-2 analog Zeydovio to improve intestinal absorption.
💉 EMA Recommends Approval for Pertuzumab Biosimilar Pebrilzo: European regulators cleared the first pertuzumab biosimilar for HER2-positive breast cancer under a tailored clinical assessment framework.
🇬🇧 UK AI Oversight Panel Recommends "L-Plate" Staged Framework for Health AI: An NHS-backed expert commission formally recommended staged, heavily guarded authorizations before new clinical AI models receive full market deployment.FDA Proposes Major Rule Overhaul to Modernize Global Drug Manufacturing Registrations: Federal regulators introduced a sweeping framework intended to digitize, clean, and aggressively enforce automated reporting standards for both domestic and foreign commercial pharmaceutical manufacturing facilities
🛒 Funding roundup:
Company / Partnership | Funding Amount | Focus Area | Location | Investors / Partners |
Angle Health | $600.0M (Equity) | Tech-enabled health insurance platform for SMBs | San Francisco, US | Private equity & healthcare growth funds |
Encoded Therapeutics | $275.0M (Series F) | AAV gene therapies for neurodevelopmental disorders | South San Francisco, US | Institutional healthcare syndicate |
Sling Therapeutics | $123.0M (Series C) | Oral small-molecule therapies for thyroid eye disease | Ann Arbor, US | Life sciences venture syndicate |
BrainChild Bio | $116.0M (Series A) | Precision CAR-T cell therapies for pediatric brain tumors | Seattle, US | Undisclosed institutional biopharma investors |
Aureka Biotechnologies | $100.0M (Series B) | AI-native therapeutic peptide & protein engineering | San Francisco, US | Life sciences venture syndicate |
Moonwalk Biosciences | $70.0M (Series B) | Epigenetic editing & precision genomic medicine | South San Francisco, US | Alpha Wave Ventures & YK Bioventures (Co-leads), Eli Lilly, Gaorong |
Dualitas Therapeutics | $36.5M Upfront (Partnership) | Bispecific antibody discovery for immunology & inflammation | South San Francisco, US | Roche |
Ayble Health | $16.0M (Series A) | AI-enabled virtual GI & autoimmune care clinic | Boston, US | Neon (Lead), Unum Ventures, Upfront Ventures, M13, Cleveland Clinic Ventures, DigiTx, Accomplice |
Norbert Health | $14.0M (Series A) | Contactless vital sign monitoring & ambient health sensing | Brooklyn, US | Early-stage digital health & healthtech VCs |
PuraVida AI | $500K (YC Seed) | AI copilot for clinical trial enrollment & protocol workflows | San Francisco, US | Y Combinator |
🎥Brain-Computer Interface
Brain-computer interfaces are officially moving out of research labs and into real clinical practice 🧠⚡.
ABILITY Neurotech just completed a first-in-human implantation of a novel BCI platform designed to restore communication for people with severe neurological impairment 🏥.
For patients living with conditions like late-stage ALS or severe stroke, losing the ability to speak or move often leads to profound isolation. Fully implantable BCI technology offers a direct pathway to bridge that gap 🌉.
Three key things make this milestone significant ✨:
1️⃣ A fully wireless design. By eliminating external wires passing through the skin, the system significantly reduces infection risks while making the device far more comfortable for daily home use 🛡️.
2️⃣ Real-time intent decoding. The platform captures high-density neural signals to translate intended speech and movement into digital commands with sub-second responsiveness 💻.
3️⃣ Restoring true agency. It is not just about moving a cursor on a screen. The goal is giving patients independent access to messaging, smart home tools, and digital communication without relying on constant caregiver assistance 🗣️.
The journey from a successful first-in-human trial to broad clinical availability takes time, rigour, and careful long-term monitoring ⏱️.
How do you see BCI technology integrating into mainstream healthcare and neuro-rehabilitation over the next decade? 💬👇
🏢Job Opportunities
Listed chronological order (latest at the end!).
When you apply tell the company you heard about the role @ The Fix! (Click for link to listing)
💡Senior Director, Clinical Quality, Omada health (US)
💡Head of Clinical AI, Sanome (UK)
💡Senior Product Manager, Blue Health Intelligence (Netherlands)
💡Principal Software Engineer, Phlo (UK)
💡Senior Program Officer/Program Officer Path (india, Indonesia)
💡VP, Commercial, 52 North (UK)
💡Clinical Product Lead, C the Signs (UK)
💡 Health Economics & Market Access Senior Manager / Deputy - SEA and Phamaging Countries, AEIRA (SG)
💡 QA Senior Manager, AEIRA (SG)
💡 Commercial Excellent Deputy, AEIRA (SG)
💡 Quality Officer, HeliosX (UK)
💡 Product Manager - Patient Experience, Conduit Health (US)
💡 Director, Product Management, Hinge Health (US)
💡 Senior Product Manager - Payments, Flo Health (UK)
💡 Sr. Product Manager, Karoo Health (US)
💡 Clinical Lead - New Products, Eucalyptus (UK)
💡 Medical Director - Nourish Medical, Nourish (US)
💡 Lead Director, Clinical and Digital Health Programs, CVS Health (US)
💡 Clinical Advisor, Voy (UK)
💡 North America Sales Lead, Vira Health (Canada)
💡 Head of Partnerships, 01Health (UK)
💡 Product Manager, Health and Home Infrastructure, Google (UK)
💡 Associate, Prova Health (UK)
💡 AI Implementation Manager, Cambridge University Hospitals NHS Foundation Trust (UK)
💡Clinical Safety Officer, Healthtech-1 (UK)
💡Director, Partnerships & Enterprise International Growth, Oura (UK)
💡Clinical Manager, Cochlear (UK)
💡Clinical Advisor, Voy (UK)
💡Co-founding CEO, Daya Ventures (Sweden)
💡Clinical Doctor, Zava (Ireland)
💡Founding Research Scientist, MenSC Labs (SG)
💡Vice President, Clinical Strategy & Integration — Oscar Health – (US)
💡Senior Transformation Manager — Suvera Ltd – (UK)
💡Medical Advisor, Rare Disease — Novo Nordisk – (Denmark)
💡Clinical Safety Officer — Healthtech-1 – (UK)
💡Clinical Specialist — Microsoft AI – (US)
💡Clinical Editor, BMJ Women's Health — BMJ Group –(UK)
💡Healthcare Strategic Lead, UK Public Sector Healthcare — BCG – (UK)
💡Clinical Safety Specialist — Amazon Web Services (AWS) – (US)
💡Clinical Safety Specialist — Assuric – (UK)
💡 Programme Director Cohort 3 — ARIA – (UK)
💡 Partnerships Manager, Medical Devices — Proximie – (UK)
💡 Chief Digital Information Officer — Great Ormond Street Hospital for Children NHS Foundation Trust – (UK)
💡 Clinical Associate in GTM [London] — Heidi – (UK)
💡 Clinical Specialist — Microsoft AI – (UK)
💡 Director, Partnerships & Enterprise International Growth — Ōura – UK
💡 Member of Product Staff – Health AI — Microsoft AI – (UK)
💡 CTO – Diagnuvo Health Ltd– (UK)
💡 Growth & Partnerships Lead, Lucence (SG)
💡 General Manager of Asia Pacific, Stellaromics (SG)
💡 Enterprise Account Executive, Heidi (SG)
💡 Product Lead, Synapxe (SG)
💡 Life Science Scientist, PatSnap (SG)
💡 Open Positions (43), Abridge — Various
💡 Deployment Strategist, Charta Health(US)
💡 Staff Product Manager - Life Sciences, Dandelion Health (US)
💡 Entrepreneur-in-Residence, Digital Health (LG NOVA), LG Electronics (LG NOVA) (US)
💡 Head of Product (backed by Y Combinator, $5M+ ARR, $23M+ raised), Legion Health (US)
💡 Technical Program Manager, Integrations - Health Systems, Heidi (SG)
💡 Manager, APAC Business Development and Partnership, Dexcom (SG)
💡 Founding Clinical AI Lead, Atomic (US)
💡 Founding Head of Product, Alpaca Health (US)
💡 AI Transformation Leader, Qualified Health (US)
💡 Founding AI Deployment Lead - US Market, Vocca (US)
💡 Health Plan Strategy Lead, Abby Care (US)
💡 Strategic Solutions & Market Expansion Lead (Life Sciences), Causaly(US)
💡 Enterprise Business Development Representative, Heidi (US)
💡 Managing Director of New Ventures - Cedars-Sinai, Redesign Health (US)
💡 Head of Product - Integrations, PHIL (remote)
💡 Founding Product Manager, Platform + Consumer + AI (backed by Y Combinator, $5M+ ARR, $23M+ raised), Legion Health(US)
💡 Senior Product Manager, Healthcare, Whoop (US)
🌆Upcoming Events
🍵Upcoming Tech Brews meetings
London
- Thursday 24 Sept, 3:00PM Harmony Meta
- 15 Oct (provisional)Singapore
- Sat 26 Sept, 9:00AM "Networking"
- Tues 29 Sept, 5:30PM “Patent Strategy”Bangkok
- 28 Sept, 6:00PM with Guest Speaker: Ajeesh AshrafEdinburgh
- Thur 23 Oct, 5:30PM “Networking”San Francisco
- Wed 16 Sept, 6:00PM Dream State: AI after Dark Opening PartyJapan
- Sat 17 Oct, 9:00AM with Guest speaker Shohei IkomaTaipei
- Fri 20 Nov, 4:30PM Pop Up
🌏 Global MedTech & Health Summits
September 22–23, 2026: World Medical Innovation Forum Boston, USA Global forum convening healthcare leaders, innovators, researchers, investors, and policymakers to explore emerging opportunities, technologies, and challenges shaping the future of medical innovation.
September 28–30, 2026: Bitz & Pretzels, Munich | 28–30 Munich, Germany Bitz & Pretzels hosts 7,500 founders, investors, and industry leaders for three days of learning, networking, and doing business during Munich Oktoberfest.
September 29, 2026: HETT Show London, UK Innovation that transforms patient outcomes through technology, transformation, and collaboration, with insights into the latest technology trends, peer successes and challenges, and opportunities to upskill.
September 30, 2026: Sifted Summit | 8–9 UK A summit bringing together leaders from Europe’s fastest-growing technology brands.
October 11, 2026: Africa HealthTech Summit Rwanda Exploring how health technology can scale innovation through universal health coverage.
October 11–13, 2026: World Health Summit Berlin, Germany Global forum addressing health equity, pandemic preparedness, climate and health, digital health, and governance.
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Editorial: Terence Tan
Events & Opportunities: Eugene Fang
Disclaimers- Views, thoughts, and opinions expressed in the text belong solely to the author, and not necessarily to the author's employer, organization, committee or other group or individual. The above analysis is also purely personal opinion and should not be taken as professional advice. All content intended for informational purposes.
Disclosures- At the time of this post, The Fix or the team have not received any sponsorship, whether financial or in-kind for this post. There is no equity or financial stake in any of the private companies mentioned above
